Retinal vessel impairment as a biomarker of vascular ageing process – Correlation to cognitive decline and cardiovascular events (WP4) C. Helmer, MN Delyfer, T Couffinhal (Inserm U897; Inserm U1034 - Department of Cardiovascular diseases - Department of Ophthalmology. Medical Unit « Rétine, Uvéites et Neuro-Ophtalmologie »)
Ocular fundus analysis can provide information on pathological changes caused by some systemic diseases. In vivo noninvasive analyses of the retina are routinely performed in outpatient practice using posterior pole color images, wide-field images and spectral-domain Optical Coherence Tomography (SD-OCT). On the one hand, fundus images allow the evaluation of the structure of retinal vessels and to identify measurable abnormalities in diameter, color and/or tortuosity (vascular fractal dimension and vascular branching angle) that can correlate with the state of systemic diseases. On the other hand, SD-OCT analyses enable transversal analyses of the retina and its vasculature with images close to histological sections, together with confocal analyses of retinal abnormalities. The recent technological progresses of adaptative optics even allow effective measurement of the thickness of retinal vessel walls.
- Correlation between retinal vessel structure alteration, MRI white matter lesions and cognitive decline
- Correlation between retinal vessel structure alteration and cardiovascular events