CXCR3 and vascular ageing

CXCR3 and vascular ageing (WP5) : A Bikfalvi, C Duplaa, J Badaut, S Debette, C Tzourio (Inserm U1029; Inserm U1034; Inserm U897; CNRS UMR 5287)

Cellules endothéliales Cellules endothéliales

CXC chemokines represent a large family of homologue peptides exhibiting multiple biological activities. They play a crucial role in HIV biology, inflammation, malaria infection, neurogenereation, and atherosclerosis (Mishra et al., 2011; Rostene et al., 2011). One of their receptors, CXCR4 is involved in the entry of HIV virus in immun cells (Murakami and Yamamoto, 2010). In the vasculature they exhibit paradoxical biological effects promoting atherosclerosis by inducing recruitment of inflammatory cells, their activation and differentiation within atherosclerotic plaques (Aidoudi and Bikfalvi, 2010). On the other end, they exert pro- or anti-angiogenic effects depending on the presence of the structural motif ELR(Keeley et al., 2011; Vandercappellen et al., 2011). In the frame of this ATT VIVA, we will address the role of CXCR3 and of one of its ligands.

  • Signaling studies
  • Development of a diagnostic detection kit for CXCR3 ligand CXCL4L1
  • CXCR3 and hindlimb arteriopathy
  • CXCR3 and trauma brain injury
  • CXCR3 and MRI-markers of vascular brain injury 

Updated on 09/06/2016